Edited by edmund j lewis melvin m schwartz stephen m korbet and daniel tak mao chan abstract thoroughly updated and revised this new edition reflects the numerous advances in clinical management of patients in the last decade including new understanding of pathogenesis a new classification and the considerable advances in therapeutic options for the disease. Lupus nephritis second edition edited by edmund j lewis melvin m schwartz stephen m korbet and tak mao chan oxford clinical nephrology series reflects recent advances in the management of patients including clinical characteristics the morphologic abnormalities which occur in the kidney of patients with glomerulonephritis and treatment approaches for these patients includes the . Lupus nephritis is a strikingly heterogeneous condition this heterogeneity is exemplified in the role played by autoantibodies serological studies provide evidence that a number of different antibodies may be linked to the occurrence of renal involvement in patients with sle but some are only important in a small subset of patients anti dsdna antibodies are the most commonly seen . The management of severe lupus nephritis entails considerations of treatment efficacy and the prevention and treatment of disease related complications and drug induced toxicities which can present immediately or emerge during long term follow up the heterogeneity in clinical course and responses to treatment presents additional challenges accumulating data over the past decade have . Edmund j lewis melvin m schwartz stephen m korbet oup oxford nov 4 2010 medical 325 pages 0 reviews severe inflammation of the kidney can indicate the serious negative prognosis of lupus nephritis when present in conjunction with systemic lupus erythematosus sle a chronic autoimmune connective tissue disease that can affect any part of the body most often harming the heart
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