While efforts are being made to identify the mechanisms of resistance and to develop novel drugs and therapeutic agents to overcome them the lack of physiologically relevant drug resistant cancer model systems remains a significant challenge drug resistance in cancer comes in two forms intrinsic resistance and acquired resistance. Drug resistance in cancer whereby a portion of cancer cells evades chemotherapy poses a profound and continuing challenge for the effective treatment of cancer the principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume a deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor . Drug resistance mechanisms in colorectal cancer dissected with cell type specific dynamic logic models eduati f1 doldn martelli v12 klinger b34 cokelaer t1 sieber a34 kogera f5 dorel m346 garnett mj5 blthgen n746 saez rodriguez j89 author information 1european molecular biology laboratory european bioinformatics institute embl ebi . A review of drug resistance in cancer analyses each biological determinant of resistance separately and discusses existing and new therapeutic strategies to combat the problem as a whole. Elucidating the mechanism by which these pathways promote drug resistance can improve the efficacy of chemotherapeutic drugs and overcome treatment failure the aim of this study was therefore to determine the effects of doxorubicin on apoptosis signalling autophagy the mapk and pi3k akt signalling pathway cell cycle control and regulators of the emt process in murine breast cancer tumours
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